ABOUT PROLEVIATE CONOLIDINE BENEFITS PATIENTS

Preliminary reports indicate conolidine may possibly inhibit specific ion channels, reducing neuronal excitability and restricting suffering signals. This system is especially applicable in neuropathic ache, wherever irregular signaling brings about persistent soreness. On top of that, conolidine appears to affect G protein-coupled receptor (GPCR)

When the opiate receptor relies on G protein coupling for sign transduction, this receptor was identified to make the most of arrestin activation for internalization from the receptor. Otherwise, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in variable enhancement in binding efficacy. This binding